Application of Viscoll® Collagen

Viscoll® Collagen is a versatile material adaptable to meet any application challenges in the field of regenerative medicine and tissue engineering.

Viscoll® Collagen can be used in projects aiming to translate research into clinical practice

Some proven areas of application are listed below. Please contact us for additional information.

Matrix-assisted cell transplantation

Cell transplantation has great potential for treating degenerative diseases. However, obstacles such as poor engraftment and survival after transplantation severely limit the possibilities of this method. Matrix-assisted cell transplantation can solve the problem of cell survival and integration into the surrounding tissues. Viscoll® Collagen is a biodegradable collagen type I that contains cell adhesive sequences and upon in vivo implantation, promotes angiogenesis.

At present, two medical devices made of Viscoll® collagen are undergoing clinical trials that may be used for matrix-assisted cell transplantation:

Viscoll® collagen membrane for corneal repair

Viscoll® collagen for repairing soft tissue defects
We are open to cooperation and ready to adapt Viscoll® collagen to your task.
Heat-sensitive hydrogel
Very viscous, concentrated Viscoll® collagen solution, cured by heat and neutralization. It is possible to create new compositions by mixing collagen with growth factors, bone chips, dispersed tissues, cells, etc.

Improved biomechanical properties

Prefabricated collagen membranes are strong, elastic and transparent. Their mechanical properties allow them to be fixed at the implantation site with classic surgical sutures.
Perfect Biocompatibility
Collagen hydrogels prepared from concentrated Viscoll® collagen solutions do not restrict cell migration from the surrounding tissues into the material after its implantation, thus initiating the natural process of tissue regeneration.

Medical devices based on VISCOLL®Collagen

Viscoll® collagen for repairing soft tissue defects
  • Purpose
    The product is designed to replace soft tissue defects.
  • Scope of application

    Cosmetology, dermatology, plastic surgery.

  • Stage of state registration as a medical device

    Clinical trials are being conducted.

Key Features
  • Sterile collagen solution at a concentration of 80 mg/ml
  • Can be mixed with biologically active substances (growth factors, platelet-rich plasma, osteoinductive materials, etc.)
  • Can be mixed with cell suspension
  • Time for hydrogel formation at +37°С and a neutral pH range for 3-5 minutes
  • Can be used as a bioink for 3D bioprinting
  • Ensures prolonged cell survival after transplantation
Viscoll® collagen membrane for corneal repair
  • Purpose
    The product is intended to replace the surface of the eye through surgical intervention
  • Area of application
  • Stage of state registration as a medical device
    Clinical trial approval obtained. Site search underway
Key Features
  • Durable, clear, biocompatible collagen membrane
  • Can be secured with surgical sutures
  • Ensures prolonged cell survival
  • Permeable to low molecular weight substances
  • Permeable to host cells upon implantation
3D bioprinting

Additive technologies, particularly 3D bioprinting, are the fastest growing area in tissue engineering. This method makes it possible to create layer-by-layer structures of complex geometry with a given pore size to repair defects in soft and hard tissues. Hydrogels containing collagen are the most popular bioink option. But more importantly, materials made from pure collagen using 3D bioprinting technology have a very high chance of being implemented in clinical practice in the near future. Viscoll®Collagen solutions can be used as universal bioinks for creating three-dimensional structures using direct extrusion 3D bioprinting.

In printed structures, the survival rate of human cells is more than 90%.
Direct 3D bioprinting
Concentrated Viscoll® Collagen solutions can be printed directly with a resolution of up to 300 microns without the use of supporting substrates.

Ease of use

Preparing bioinks for 3D bioprinting takes no more than 5-10 minutes.

Ready-made solutions for bioprinting

Concentrated Collagen Solutions

Key Features

  • Sterile collagen solution with a concentration of 80 mg/ml
  • Can be mixed with other extracellular matrix proteins
  • Can be mixed with biologically active substances (growth factors, platelet-rich plasma, osteoinductive materials, etc.)
  • Can be mixed with cell suspension
  • Ensure long term cell survival
  • Can be used as a bioink for bioprinting
Research & Development

Until recently, the extracellular matrix was considered to be just an ordinary, inert scaffold supporting cells. However, over the last two decades, its fundamental role in key aspects of cell biology has been proven. An important event was the discovery of the phenomenon of the regulation of differentiation of mesenchymal stem cells and other types of stem cells according to the specified properties of the surrounding extracellular matrix. We produce highly purified extracellular matrix proteins (collagen types I-V, fibronectin, vitronectin,and laminin), which can be used to create a natural niche for cells for both basic scientific research and applied research in regenerative medicine.

Our Products
Wide range of collagen concentrations
An adjustable concentration of type I collagen in solution allows to vary the physical properties of the final hydrogel depending on the desired biomedical results and the type of cells used.
Highly purified proteins of the ECM
The possibility of adding collagens of other types (collagen types II-V) and other extracellular matrix proteins (vitronectin, fibronectin, and laminin) determines cell behavior and the possibility of creating a fully functional tissue equivalent.
A variety of product formats
Our capabilities are not limited to the products presented. As manufacturers, we can adapt our products to your task.